MRI of the Liver: A Practical Guide - download pdf or read online

By J.A. Robinson Philip, Janice Ward

ISBN-10: 0824728718

ISBN-13: 9780824728717

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Radiology 2005; 236:166–177. Gadoxetic Acid 15. 16. 17. Hamm B, Staks T, Muhler A, et al. Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. Radiology 1995; 195:785–792. Huppertz A, Balzer T, Blakeborough A, et al. Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings. Radiology 2004; 230:468–478. Huppertz A, Haraida S, Kraus A, et al.

6). SPIO produces a prolonged reduction in liver signal on both T1w and T2w images. Consequently, post-Gd lesion enhancement is more pronounced after prior injection of SPIO due to the reduced signal of background liver and hypervascular lesions are particularly conspicuous (Fig. 38). However, hypovascular lesions may be less conspicuous because Gd enhancement of liver parenchyma is less pronounced after SPIO. 1 cm) were detected with SPIO and Gd images combined compared with unenhanced or SPIO-enhanced images alone, although a few lesions were only visible with SPIO enhancement.

35). Mangafodipir is limited in its ability to characterize lesions. Although its use reliably distinguishes between hepatocellular and most non-hepatocellular tumors, benign and malignant lesions may show similar enhancement patterns (Fig. 36). Uptake can be seen in all tumors of hepatocellular origin including HCC and has rarely been observed in neuroendocrine metastases. Gadobenate may have a role in distinguishing FNH from adenoma. In a recent study of contrast media in histologically-confirmed hepatocellular lesions, adenomas showed little or no uptake of gadobenate on delayed images, while uptake and retention of mangafodipir and SPIO was consistently present.

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MRI of the Liver: A Practical Guide by J.A. Robinson Philip, Janice Ward


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