Download e-book for kindle: Pharmacokinetics: A Modern View by Louis W. Busse (auth.), Leslie Z. Benet, Gerhard Levy, Bobbe

By Louis W. Busse (auth.), Leslie Z. Benet, Gerhard Levy, Bobbe L. Ferraiolo (eds.)

ISBN-10: 1461297257

ISBN-13: 9781461297253

ISBN-10: 1461327997

ISBN-13: 9781461327998

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J. Stokes Machine Co. and some very mechanically adept shop workers at SK&F, a tableting machine was devised to manufacture multilayered tablets. The idea was to formulate one layer as a typical quick release dose, and the other as a thin layer with wide cylindrical dimensions, so that dissolution of the remaining drug would approach zero-order release kinetics. The dose and release rate over a period of hours should approach the rate of theophylline loss from the body at therapeutic blood concentrations, thus requiring the patient to take only one tablet, morning and night.

This paper, plus those published in 1956 through 1958 (7-12), which consisted mainly of our very extensive investigations with SETD in humans during 1954-56, stirred the interest of a lot of pharmaceutical scient is ts and educators. Within a few years hundreds of pharmacy-oriented people were undertaking research in the kinetics of drug absorption, distribution, metabolism and excretion. EARLY DAYS OF PHARMACOKINETICS 43 In 1954, a plot I made of penicillin G concentration data illustrating a biologic half-life of 30 minutes had a profound effect on my thinking about this drug.

In 1958, Sid published a series of papers (16-18) with graduate student Wilfred Crowell under the major heading "The Kinetics of Rectal Absorption" in the Scientific Edition of the Journal of the American Pharmaceutical Association. These papers were important for a number of reasons. First, the work was good. The studies were recognized with the awarding of the Ebert Prize to Sid iri 1959. This Prize is awarded for the best work published in journals of the American Pharmaceutical Association during the previous year.

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Pharmacokinetics: A Modern View by Louis W. Busse (auth.), Leslie Z. Benet, Gerhard Levy, Bobbe L. Ferraiolo (eds.)

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